Methods: We used an adaptive optics visual simulator (AOVS) with extended capabilities for chromatic aberration manipulation. The AOVS incorporated a liquid crystal on silicon spatial light modulator (LCoS-SLM) as correcting device. Dedicated phase masks were programmed on LCoS-SLM to dynamically alter the induced CA. Defocus was independently controlled by a tunable lens (TL). Two conditions of modified longitudinal CA were induced: corrected (C) and doubled (D) CA. The former consisted of the compensation of the natural CA of the eye, while the latter corresponded to the twofold enlargement of the CA, while still maintaining the sign of the natural case. Those cases were compared with the natural case (N). Through-focus visual acuity (VA) was measured in 4 subjects with paralyzed accommodation. Computational simulations of through-focus VA were also performed, using a ray-tracing software able to include the individual aberrations of each subject.
Results: The case C showed an average reduction of VA of 16 % compared to case N. Case D showed a drop of 23 %. While experimental through-focus VA for case N resembled the theoretical calculations, the predicted values for cases C and D did not match the experimental results. Those were significantly lower than expected from simulations.
Conclusions: Through focus VA for three different conditions of CA were measured with a new method based on the generation of phase masks in an AOVS. Both the corrected and double CA cases presented a reduction in VA compared to the natural case. There was an overestimation of the through focus VA for cases C and D from simulations as compared to the experimental results. This fact might indicate that additional neural factors are present, perhaps impacting vision under modified chromatic conditions. The results can help to optimize optical corrections, as intraocular lenses and others, attempting to include CA manipulation to enhance vision.