Purpose: The Visual Adaptive Optics (VAO) is an adaptive optics visual simulatorwith an embedded Hartmann–Shack aberrometer that can give objective and subjective refraction measures. The aim of the present study was to compare the findings of the objective and subjective refractions from the VAO with a commercial autorefractometer (Topcon Corp., Tokyo, Japan) and a subjective refraction by an optometrist. The influence of age, refractive error type, and presence of ocular diseases was ascertained.

Methods: The refractive error was obtained in 469 participants using the four techniques mentioned. Data were analyzed with power vectors mean spherical equivalent, the vertical Jackson-Cross-Cylinder, and the oblique Jackson-Cross-Cylinder. Age, refractive error type (myopia, emmetropia, hyperopia) and presence of ocular diseases (yes, no) were included as covariates. Agreementwas assessed using the 95% interval of agreement.

Results: The median spherical equivalent difference and the interval of agreement for all the participants with the VAO subjective, VAO objective, and autorefraction with the clinical subjective refraction were (+0.13, 1.80 diopters [D]), (+0.38, 1.80 D), and (−0.38, 2.10 D), respectively. When considering only healthy participants, the results were (+0.06, 1.70 D), (+0.38, 1.60 D) and (−0.25, 1.80 D), respectively.When considering only those participants with any ocular condition, the results with VAO subjective, VAO objective and autorefraction were (+0.13, 2.50 D), (+0.31, 2.70 D), and (−0.50, 4.80 D), respectively.

Conclusions: The VAO subjective refraction is more accurate than VAO objective refraction and autorefraction, regardless of refractive error, age, or the presence of ocular conditions. The presence of ocular conditions significantly deteriorates the accuracy of all refraction methods.

Translational Relevance: Reported clinical comparisons between different types of standard refraction methods and a new adaptive optics refraction instrument (VAO) are in good agreement and support the further development of this method to increase refraction accuracy and to refract quicker than standard procedures.